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”Spice (drug)” redirects here. For the fictional drug in Frank Herbert’s Dune novels.

Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach.^[1]

These novel psychoactive substances should not be confuse with synthetic phytocannabinoids (THC or CBD obtain by chemical synthesis) or synthetic endocannabinoids from which they are in many aspects distinct.^[2][3][4]

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Typically, synthetic cannabinoids are spray onto plant matter^[5] and are usually smoke^[6] although they have also been ingest as a concentrate liquid form in the US (United States) and UK (United Kingdom) since 2016.^[7]

They are often label “not for human consumption” for liability defense.^[8]

A large and complex variety of synthetic cannabinoids are design in an attempt to avoid legal restrictions on cannabis, making synthetic cannabinoids designer drugs.^[6]

Most synthetic cannabinoids are agonists of the cannabinoid receptors.

These synthetic analogs often have greater binding affinity and greater potency to the CB₁ receptors.

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There are several synthetic cannabinoid families (e.g. AM-xxx, CP-xx,xxx, HU-xx, JWH-xxx) which are classified by the creator of the substance (e.g. JWH stands for John W.

Huffman), which can include several substances with different base structures such as classical cannabinoids and unrelate naphthoylindoles.^[11]

Synthetic marijuana compounds begin to  manufacture and sold in the early 2000s.^[6]

From 2008 to 2014, 142 synthetic cannabinoid receptor agonists were report to the European Monitoring-Center for Drugs and Drug Addiction (EMCDDA).^[12]

Synthetic cannabinoids

Report user negative effects include palpitations, paranoia, intense anxiety, nausea, vomiting, confusion, poor coordination, and seizures.

In 2018, the United States Food and Drug Administration warn of significant health risks from synthetic

cannabinoid products that contain the rat poison brodifacoum, which adds because

it is thought to extend the duration of the drugs’ effects.^[15]

Severe illnesses and death have results from this contamination